- LPU Ph.D student will present his research work at Vienna in Austria in the last week of September 2015
- Got breakthrough to check blood-cancer by having further researches on his important biological findings
- Facing continuous three deaths in the family due to cancer, LPU researcher got alert to analyze the very being of this killer-disease
- LPU Scientist has researched on Chronic Myeloid Leukemia (CML) type of blood-cancer
Facing one by one three deaths in the family (of his father, father’s elder & younger brother) due to cancer, LPU researcher is alert and determined to analyze the root cause of this dangerous disease. He does not want others to suffer as he has himself suffered irreparable loss. Explaining scientifically, Yogender informed: “Cancer is a disease caused by certain changes in some genes called proto-oncogene. It is a gene that has the potential to cause cancer. Along with these genes several other molecular pathways also play important role in causing cancer. In simple terms, malignant activation of a gene is associated with the continuing conversion of normal cells into cancer cells. My study is based on examining the significance of a pathway called “TGF-B-Smad pathway” in CML patients.
Elaborating Yogender continued, “In normal scenario, this pathway (TGF-B-Smad pathway) acts to control many cellular processes like self death, cell maturation, expansion and more. As one of the main causes of change in function of genes is change in the sequence of their basic building blocks called nucleic acid, I and my team decided to study these changes (mutation). In our study, we sequenced all active parts of genes along with their boundaries with inactive parts of almost all the genes of this pathway. For those who have deep biological knowledge these genes are 8 in number: Ligand (TGFB1); Receptor genes (TGFBR1 & TGFBR2); Intermediates (SMAD2, SMAD3 and SMAD4); and, Inhibitors (SMAD6 &SMAD7). Analyzing we observed that more than 60 mutations were found in all of these 8 genes collectively. Some of these mutations are novel in finding, and now we are further studying mutations relevance in understanding the mechanism of CML. This will help in curbing the fatal disease in future.”